Your path to Cellular Health

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Mining is a cyclical industry, so organisations have been wary of making big changes, but trends suggest that this could be changing. According to the Mine-Site Technology Adoption Survey, 2022 Update analysis from GlobalData, 39% of mines are expected to invest in battery electric vehicles in the coming two years, compared with only 23% in the Q4 2020 survey.

So, what is pushing this increased interest in battery electric vehicles? Decarbonisation is one clear factor, with sustainability being a pressing global issue. Other growing investment areas in mining technology, such as management software, collision avoidance, fatigue detection, and predictive maintenance, imply that mines are increasingly looking to utilise technology for safety and optimising productivity.

TetraSOD^® is a patented, science-backed unique marine ingredient derived from the microalgae Tetraselmis chuii, optimized to protect your cellular health. It is much more than just a SOD ingredient; it is a low dose (25 mg/day) powerful direct antioxidant but also, what is much more important, a potent indirect antioxidant.

This indirect effect is demonstrated by the induction of endogenous SOD, CAT, and GPX activity in your cells. TetraSOD^® modulates many cellular health factors such as redox balance, inflammation, genome stability, immune system, mitochondrial function, structural integrity, cellular signaling, and proteostasis, with NRF2 and SIRT1 appearing as key players.

TetraSOD^® first protects the cells by the indirect activation of the main antioxidant enzymes: SOD, CAT, and GPX, which are responsible for free radical scavenging, avoiding oxidative stress and creating a perfect shield for your cells.

But in addition to this indirect antioxidant activity, TetraSOD^® exhibits anti-inflammatory effects, and stimulates several factors contributing to cellular health, highlighting the following ones but not limited to:

TetraSOD^® first protects the cells by the indirect activation of the main antioxidant enzymes: SOD, CAT, and GPX, which are responsible for free radical scavenging, avoiding oxidative stress and creating a perfect shield for your cells.

But in addition to this indirect antioxidant activity, TetraSOD^® exhibits anti-inflammatory effects, and stimulates several factors contributing to cellular health, highlighting the following ones but not limited to:

• Mitochondrial function: Through activation of SIRT1, NRF2, AIFM1, SOD2, PRDX3, and MAPK14/p38, TetraSOD^® promotes mitochondrial biogenesis, regulating oxidative phosphorylation and energy (ATP) production, and protecting mitochondria from reactive oxygen species (ROS). VO2 max increase is induced.
• Genome stability: Reduces double-strand DNA breaks, enhancing DNA repair capacity, and protects telomeres from shortening, decreasing the amount of critically short telomeres.
• Antioxidant and anti-inflammatory function: TetraSOD^® activates both NRF2, the key master transcription factor that drives cellular antioxidant mechanisms, and SIRT1, down-regulating NF-B function and thus the pro-inflammatory cytokine expression it mediates (IL-1, TNF, IFN), and up-regulates the expression and serum levels of IL-10, the main anti-inflammatory cytokine.
• Cognitive function: Activates CREB1, BDNF, NTNG, and DLG4, which collectively are crucial factors for synaptic plasticity and connections, synaptic receptor organization, neuronal survival, learning, and memory consolidation.

TetraSOD^® is the only ingredient that in vivo has been proven to simultaneously activate NRF2 and SIRT1 in human tissues. Importantly, TetraSOD^® acts as a master modulator within the cell, activating cellular responses that need enhancement.

Based on consultation to consumers routinely supplemented with TetraSOD^® formulated products, reported benefits within 4 weeks includes:

• Enhanced energy and vitality
• Improved mood and cognitive function
• Reduced oxidative stress
• Better cellular health functions
• VO2 max increase
• Improved recovery after exercise
• Increased performance by VO2 max improvement